PF07940

Heparinase II/III-like protein

Pfam entry
Member databasePfam
Pfam typefamily
Short nameHepar_II_III
ClanGal_mutarotase
Author Fenech M;0000-0001-7933-4617 Eberhardt R;0000-0001-6152-1369
Sequence Ontology0100021

Description

This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II (Swiss:Q46080) and heparinase III (Swiss:Q59289). The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin
[1]
.

References

1.Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum. Su H, Blain F, Musil RA, Zimmermann JJ, Gu K, Bennett DC. Appl. Environ. Microbiol. 62, 2723-34, (1996). View articlePMID: 8702264

Further reading

2. Structural basis of heparan sulfate-specific degradation by heparinase III. Dong W, Lu W, McKeehan WL, Luo Y, Ye S. Protein Cell 3, 950-61, (2012). View articlePMID: 23011846

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