PF08031

Berberine and berberine like

Pfam entry
Member databasePfam
Pfam typedomain
Short nameBBE
ClanFAD-oxidase_C
Author Mistry J;0000-0003-2479-5322
Sequence Ontology0000417

Description

This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine
[1]
[2]
.

References

1.Molecular characterization of berberine bridge enzyme genes from opium poppy. Facchini PJ, Penzes C, Johnson AG, Bull D. Plant Physiol. 112, 1669-77, (1996). View articlePMID: 8972604

2.Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants. Kutchan TM, Dittrich H. J. Biol. Chem. 270, 24475-81, (1995). View articlePMID: 7592663

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