Member database | Pfam |
Pfam type | family |
Short name | VIT |
Clan | Cupin |
Author | Wuster A;0000-0003-4162-5931 |
Sequence Ontology | 0100021 |
Description
Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition
[1]. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.
References
1.ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. Himmelfarb M, Klopocki E, Grube S, Staub E, Klaman I, Hinzmann B, Kristiansen G, Rosenthal A, Durst M, Dahl E. Cancer Lett. 204, 69-77, (2004). View articlePMID: 14744536
Further reading
2. VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily. Mayne R, Ren ZX, Liu J, Cook T, Carson M, Narayana S. Biochem. Soc. Trans. 27, 832-5, (1999). PMID: 10830112