PF08487

Vault protein inter-alpha-trypsin domain

Pfam entry
Member databasePfam
Pfam typefamily
Short nameVIT
ClanCupin
Author Wuster A;0000-0003-4162-5931
Sequence Ontology0100021

Description

Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition
[1]
. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.

References

1.ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. Himmelfarb M, Klopocki E, Grube S, Staub E, Klaman I, Hinzmann B, Kristiansen G, Rosenthal A, Durst M, Dahl E. Cancer Lett. 204, 69-77, (2004). View articlePMID: 14744536

Further reading

2. VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily. Mayne R, Ren ZX, Liu J, Cook T, Carson M, Narayana S. Biochem. Soc. Trans. 27, 832-5, (1999). PMID: 10830112

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