PF08557

Sphingolipid Delta4-desaturase (DES)

Pfam entry
Member databasePfam
Pfam typedomain
Short nameLipid_DES
Author Daub J;0000-0001-6022-563X Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526
Sequence Ontology0000417

Description

Sphingolipids are important membrane signalling molecules involved in many different cellular functions in eukaryotes. Sphingolipid delta 4-desaturase catalyses the formation of (E)-sphing-4-enine
[1]
. Some proteins in this family have bifunctional delta 4-desaturase/C-4-hydroxylase activity. Delta 4-desaturated sphingolipids may play a role in early signalling required for entry into meiotic and spermatid differentiation pathways during Drosophila spermatogenesis
[1]
. This small domain associates with FA_desaturase Pfam:PF00487 and appears to be specific to sphingolipid delta 4-desaturase.

References

1.Identification and characterization of a sphingolipid delta 4-desaturase family. Ternes P, Franke S, Zahringer U, Sperling P, Heinz E. J. Biol. Chem. 277, 25512-8, (2002). View articlePMID: 11937514

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