PF08614

Autophagy protein 16 (ATG16)

Pfam entry
Member databasePfam
Pfam typecoiled coil
Short nameATG16
Author Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526
Sequence Ontology0001080

Description

Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
[1]
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References

1.Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. Mizushima N, Noda T, Ohsumi Y. EMBO J. 18, 3888-96, (1999). View articlePMID: 10406794

Further reading

2. Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy. Matsushita M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62, 1021-3, (2006). PMID: 17012802

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