Member database | Pfam |
Pfam type | coiled coil |
Short name | ATG16 |
Author | Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526 |
Sequence Ontology | 0001080 |
Description
Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
[1].
References
1.Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. Mizushima N, Noda T, Ohsumi Y. EMBO J. 18, 3888-96, (1999). View articlePMID: 10406794
Further reading
2. Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy. Matsushita M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62, 1021-3, (2006). PMID: 17012802
Integrated to
Representative structure
7xfr: Crystal structure of WIPI2b in complex with the second site of ATG16L1