PF08650

DASH complex subunit Dad4

Pfam entry
Member databasePfam
Pfam typefamily
Short nameDASH_Dad4
Author Wood V;0000-0001-6330-7526 Finn RD;0000-0001-8626-2148
Sequence Ontology0100021

Description

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis
[2]
. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro
[3, 1]
.

References

1.Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Westermann S, Avila-Sakar A, Wang HW, Niederstrasser H, Wong J, Drubin DG, Nogales E, Barnes G. Mol. Cell 17, 277-90, (2005). View articlePMID: 15664196

2.The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJ. Genes Dev. 16, 183-97, (2002). View articlePMID: 11799062

3.The yeast DASH complex forms closed rings on microtubules. Miranda JJ, De Wulf P, Sorger PK, Harrison SC. Nat. Struct. Mol. Biol. 12, 138-43, (2005). View articlePMID: 15640796

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.