PF08726

Ca2+ insensitive EF hand

Pfam entry
Member databasePfam
Pfam typedomain
Short nameEFhand_Ca_insen
ClanEF_hand
Author Mistry J;0000-0003-2479-5322
Sequence Ontology0000417

Description

EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition
[1]
.

References

1.Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex. Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A. Nat. Struct. Biol. 8, 853-7, (2001). View articlePMID: 11573089

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