Member database | Pfam |
Pfam type | domain |
Short name | EFhand_Ca_insen |
Clan | EF_hand |
Author | Mistry J;0000-0003-2479-5322 |
Sequence Ontology | 0000417 |
Description
EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition
[1].
References
1.Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex. Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A. Nat. Struct. Biol. 8, 853-7, (2001). View articlePMID: 11573089
Integrated to
Representative structure
6ts3: EF-hands 3 and 4 of alpha-actinin in complex with CaMKII regulatory segment