PF08763

Voltage gated calcium channel IQ domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameCa_chan_IQ
ClanEF_hand
Author Mistry J;0000-0003-2479-5322
Sequence Ontology0000417

Description

Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin
[1]
. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).

References

1.Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Van Petegem F, Chatelain FC, Minor DL Jr. Nat. Struct. Mol. Biol. 12, 1108-15, (2005). View articlePMID: 16299511

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