PF08915

Archaea-specific editing domain of threonyl-tRNA synthetase

Pfam entry
Member databasePfam
Pfam typedomain
Short nametRNA-Thr_ED
Author Mistry J;0000-0003-2479-5322 Sammut SJ;0000-0003-4472-904X
Sequence Ontology0000417

Description

Archaea-specific editing domain of threonyl-tRNA synthetase, with marked structural similarity to D-amino acids deacylases found in eubacteria and eukaryotes. This domain can bind D-amino acids, and ensures high fidelity during translation. It is especially responsible for removing incorrectly attached serine from tRNA-Thr. The domain forms a fold that can be be defined as two layers of beta-sheets (a three-stranded sheet and a five-stranded sheet), with two alpha-helices located adjacent to the five-stranded sheet
[1]
.

References

1.A D-amino acid editing module coupled to the translational apparatus in archaea. Dwivedi S, Kruparani SP, Sankaranarayanan R. Nat. Struct. Mol. Biol. 12, 556-7, (2005). View articlePMID: 15908961

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