PF08923

Mitogen-activated protein kinase kinase 1 interacting

Pfam entry
Member databasePfam
Pfam typedomain
Short nameMAPKK1_Int
ClanPF
Author Mistry J;0000-0003-2479-5322 Sammut SJ;0000-0003-4472-904X
Sequence Ontology0000417

Description

Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer
[1]
.

References

1.Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T. Proc. Natl. Acad. Sci. U.S.A. 101, 10984-9, (2004). View articlePMID: 15263099

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