Member database | Pfam |
Pfam type | domain |
Short name | MAPKK1_Int |
Clan | PF |
Author | Mistry J;0000-0003-2479-5322 Sammut SJ;0000-0003-4472-904X |
Sequence Ontology | 0000417 |
Description
Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer
[1].
References
1.Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T. Proc. Natl. Acad. Sci. U.S.A. 101, 10984-9, (2004). View articlePMID: 15263099