PF08935

Viral protein VP4 subunit

Pfam entry
Member databasePfam
Pfam typedomain
Short nameVP4_2
ClanNucleoplasmin
Author Mistry J;0000-0003-2479-5322 Sammut SJ;0000-0003-4472-904X
Sequence Ontology0000417

Description

This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice
[2]
. VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1
[1]
.

References

1.Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus. Belnap DM, Filman DJ, Trus BL, Cheng N, Booy FP, Conway JF, Curry S, Hiremath CN, Tsang SK, Steven AC, Hogle JM. J Virol 74, 1342-54, (2000). PMID: 10627545

2.Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus. Curry S, Fry E, Blakemore W, Abu-Ghazaleh R, Jackson T, King A, Lea S, Newman J, Stuart D. J Virol 71, 9743-52, (1997). PMID: 9371640

Wikipedia

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