PF08970

Sporulation inhibitor A

Pfam entry
Member databasePfam
Pfam typedomain
Short nameSda
Author Mistry J;0000-0003-2479-5322 Sammut SJ;0000-0003-4472-904X
Sequence Ontology0000417

Description

Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilised by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A)
[1]
.

References

1.Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis. Rowland SL, Burkholder WF, Cunningham KA, Maciejewski MW, Grossman AD, King GF. Mol. Cell 13, 689-701, (2004). View articlePMID: 15023339

Wikipedia

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