PF08996

DNA Polymerase alpha zinc finger

Pfam entry
Member databasePfam
Pfam typedomain
Short namezf-DNA_Pol
Author Mistry J;0000-0003-2479-5322 Sammut SJ;0000-0003-4472-904X
Sequence Ontology0000417

Description

The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. Function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain
[1]
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References

1.Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha. Evanics F, Maurmann L, Yang WW, Bose RN. Biochim. Biophys. Acta 1651, 163-71, (2003). View articlePMID: 14499601

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