PF09511

RNA ligase

Pfam entry
Member databasePfam
Pfam typefamily
Short nameRNA_lig_T4_1
ClanATP-grasp
AuthorTIGRFAMs; Coggill P;0000-0001-5731-1588 Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526
Sequence Ontology0100021

Description

Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity
[1]
. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i

References

1.Genetic and biochemical analysis of the functional domains of yeast tRNA ligase. Sawaya R, Schwer B, Shuman S. J. Biol. Chem. 278, 43928-38, (2003). View articlePMID: 12933796

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