PF10298

WhiA N-terminal LAGLIDADG-like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameWhiA_N
ClanHoming_endonuc
Author Mistry J;0000-0003-2479-5322 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

This domain is found at the N terminal of sporulation factor WhiA. This domain is related to the LAGLIDADG Homing endonuclease domain while the C terminal domain of WhiA is predicted to be a DNA binding helix-turn-helix domain
[1]
.

References

1.Bacterial DUF199/COG1481 proteins including sporulation regulator WhiA are distant homologs of LAGLIDADG homing endonucleases that retained only DNA binding. Knizewski L, Ginalski K. Cell Cycle 6, 1666-70, (2007). PMID: 17603302

Further reading

2. The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease. Kaiser BK, Clifton MC, Shen BW, Stoddard BL. Structure 17, 1368-76, (2009). View articlePMID: 19836336

3. WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2). Ainsa JA, Ryding NJ, Hartley N, Findlay KC, Bruton CJ, Chater KF. J. Bacteriol. 182, 5470-8, (2000). View articlePMID: 10986251

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