PF10373

Est1 DNA/RNA binding domain

Pfam entry
Member databasePfam
Pfam typerepeat
Short nameEST1_DNA_bind
ClanTPR
Author Mistry J;0000-0003-2479-5322 Wood V;0000-0001-6330-7526
Sequence Ontology0001068

Description

Est1 is a protein which recruits or activates telomerase at the site of polymerisation
[2]
[3]
. This is the DNA/RNA binding domain of EST1
[4]
[1]
.

References

1.The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA. Zhou J, Hidaka K, Futcher B. Mol Cell Biol 20, 1947-55, (2000). PMID: 10688642

2.Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Taggart AK, Teng SC, Zakian VA. Science 297, 1023-6, (2002). View articlePMID: 12169735

3.The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Evans SK, Lundblad V. Genetics 162, 1101-15, (2002). View articlePMID: 12454059

4.Telomere maintenance in fission yeast requires an Est1 ortholog. Beernink HT, Miller K, Deshpande A, Bucher P, Cooper JP. Curr. Biol. 13, 575-80, (2003). View articlePMID: 12676088

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