PF10401

Interferon-regulatory factor 3

Pfam entry
Member databasePfam
Pfam typefamily
Short nameIRF-3
ClanSMAD-FHA
Author Finn RD;0000-0001-8626-2148 Coggill P;0000-0001-5731-1588
Sequence Ontology0100021

Description

This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.

References

1. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Weaver BK, Kumar KP, Reich NC. Mol. Cell. Biol. 18, 1359-68, (1998). PMID: 9488451

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