Member database | Pfam |
Pfam type | family |
Short name | IRF-3 |
Clan | SMAD-FHA |
Author | Finn RD;0000-0001-8626-2148 Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0100021 |
Description
This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.
References
1. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Weaver BK, Kumar KP, Reich NC. Mol. Cell. Biol. 18, 1359-68, (1998). PMID: 9488451
Integrated to
Representative structure
5oem: Crystal Structure of Interferon Regulatory Factor 9 IAD Domain