PF10523

BEN domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameBEN
ClanHTH
Author Iyer LM;0000-0002-4844-2022 Bateman A;0000-0002-6982-4660 El-Gebali S;0000-0003-1378-5495
Sequence Ontology0000417

Description

The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription
[2]
. The BEN domain-containing protein 3 (BEND3) is shown to interact (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat and SNF2 HeliC region of ERCC6L) which stimulates the ERCC6L translocase and ATPase activities
[1]
.

References

1.A novel TPR-BEN domain interaction mediates PICH-BEND3 association. Pitchai GP, Kaulich M, Bizard AH, Mesa P, Yao Q, Sarlos K, Streicher WW, Nigg EA, Montoya G, Hickson ID. Nucleic Acids Res. 45, 11413-11424, (2017). View articlePMID: 28977671

2.BEN: a novel domain in chromatin factors and DNA viral proteins. Abhiman S, Iyer LM, Aravind L. Bioinformatics 24, 458-61, (2008). View articlePMID: 18203771

Wikipedia

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