Member database | Pfam |
Pfam type | domain |
Short name | Neuromodulin_N |
Author | Finn RD;0000-0001-8626-2148 Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0000417 |
Description Imported from IPR018947
Neuromodulin (also known as growth-associated protein 43 or GAP-43) is a component of the motile growth cones. It is membrane protein whose expression is widely correlated with successful axon elongation
[1]. It is a crucial component of an effective regeneration response in the nervous system
[2]. Although its function is uncertain, the N-terminal region is well conserved and contains both a calmodulin binding domain, and sites for acylation, membrane attachment and protein kinase C phosphorylation. Structure predictions suggest that the C-terminal region may exist as an extended, negatively-charged rod with some similarity to the side arms of neurofilaments, indicating that the biological role of neuromodulin may depend on its ability to form a dynamic membrane-cytoplasm-calmodulin complex
[2].
This entry represents the neuromodulin N-terminal domain.
References Imported from IPR018947
1.Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. Kosik KS, Orecchio LD, Bruns GA, Benowitz LI, MacDonald GP, Cox DR, Neve RL. Neuron 1, 127-32, (1988). View articlePMID: 3272162
2.Selective conservation of GAP-43 structure in vertebrate evolution. LaBate ME, Skene JH. Neuron 3, 299-310, (1989). View articlePMID: 2641999