PF11409

Smad anchor for receptor activation (SARA)

Pfam entry
Member databasePfam
Pfam typefamily
Short nameSARA
Author Pollington J;0000-0002-8158-8998
Sequence Ontology0100021

Description

Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus
[1]
. SARA recruits Smad2 to the TGF-beta receptors for phosphorylation
[1]
.

References

1.Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi Y. Science 287, 92-7, (2000). View articlePMID: 10615055

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.