PF11540

Cytoplasmic dynein 1 intermediate chain 2

Pfam entry
Member databasePfam
Pfam typefamily
Short nameDynein_IC2
Author Pollington J;0000-0002-8158-8998
Sequence Ontology0100021

Description

Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules
[1]
. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex
[1]
.

References

1.Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Williams JC, Roulhac PL, Roy AG, Vallee RB, Fitzgerald MC, Hendrickson WA. Proc. Natl. Acad. Sci. U.S.A. 104, 10028-33, (2007). View articlePMID: 17551010

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