PF11594

Mediator complex subunit 28

Pfam entry
Member databasePfam
Pfam typefamily
Short nameMed28
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0100021

Description

Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function
[2]
. Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours
[1]
.

References

1.Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation. Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Naar AM, Ramesh V. J. Biol. Chem. 282, 32152-7, (2007). View articlePMID: 17848560

2.Transcription mechanisms. Blackwell TK, Walker AK. 1-16, (2006). PMID: 18050436

Further reading

3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC. Mol. Cell 14, 685-91, (2004). View articlePMID: 15175163

4. The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of <i>C. elegans</i> development. Kostrouchova M, Kostrouch D, Chughtai AA, Kassak F, Novotny JP, Kostrouchova V, Benda A, Krause MW, Saudek V, Kostrouchova M, Kostrouch Z. PeerJ 5, e3390, (2017). View articlePMID: 28603670

5. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. Mol. Cell 14, 553-7, (2004). View articlePMID: 15175151

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