Member database | Pfam |
Pfam type | repeat |
Short name | Foie-gras_1 |
Clan | TPR |
Author | Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0001068 |
Description
Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease
[1]. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first
[1]. The C-terminus of this region contains TPR repeats.
References
1.A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Sadler KC, Amsterdam A, Soroka C, Boyer J, Hopkins N. Development 132, 3561-72, (2005). View articlePMID: 16000385