PF12188

Signal transducer and activator of transcription 2 C terminal

Pfam entry
Member databasePfam
Pfam typedomain
Short nameSTAT2_C
Author Mistry J;0000-0003-2479-5322 Gavin OL;
Sequence Ontology0000417

Description

This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. There is a conserved DLP sequence motif. STATs are involved in transcriptional regulation and are the only regulators known to be modulated by tyrosine phosphorylation. STAT2 forms a trimeric complex with STAT1 and IRF-9 (Interferon Regulatory Factor 9), on activation of the cell by interferon, which is called ISGF3 (Interferon-stimulated gene factor 3). The C terminal domain of STAT2 contains a nuclear export signal (NES) which allows export of STAT2 into the cytoplasm along with any complexed molecules.

References

1. STAT2 nuclear trafficking. Banninger G, Reich NC. J. Biol. Chem. 279, 39199-206, (2004). View articlePMID: 15175343

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