PF12794

Mechanosensitive ion channel inner membrane domain 1

Pfam entry
Member databasePfam
Pfam typedomain
Short nameMscS_TM
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description

The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this domain is one of the inner membrane domains.

References

1. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina N, Totemeyer S, Stokes NR, Louis P, Jones MA, Booth IR. EMBO J. 18, 1730-7, (1999). View articlePMID: 10202137

2. Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes. Sukharev S. Biophys. J. 83, 290-8, (2002). View articlePMID: 12080120

3. A possible unifying principle for mechanosensation. Kung C. Nature 436, 647-54, (2005). View articlePMID: 16079835

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