PF12802

MarR family

Pfam entry
Member databasePfam
Pfam typefamily
Short nameMarR_2
ClanHTH
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds
[1]
. The structure of MarR is known
[2]
and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.

References

1.The Salmonella typhimurium mar locus: molecular and genetic analyses and assessment of its role in virulence. Sulavik MC, Dazer M, Miller PF. J. Bacteriol. 179, 1857-66, (1997). View articlePMID: 9068629

2.The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF. Nat. Struct. Biol. 8, 710-4, (2001). View articlePMID: 11473263

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