PF13460

NAD(P)H-binding

Pfam entry
Member databasePfam
Pfam typedomain
Short nameNAD_binding_10
ClanNADP_Rossmann
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description
Imported from IPR016040

This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers α/β/α, where the six β-strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:


 * C-terminal domain of alcohol dehydrogenases
[1]

 * Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases)
[2]

 * N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase
[3]

 * NAD-binding domain of formate/glycerate dehydrogenases
[4]

 * N-terminal domain of sirohaem synthase
[5]

 * N-terminal domain of lactate dehydrogenase
[6]

 * N-terminal domain of 6-phosphogluconate dehydrogenase (the β-sheet is extended to 8 strands)
[7]

 * C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix
[8]

 * NAD-binding domain of certain potassium channels
[9]

 * C-terminal domain of the transcriptional repressor Rex
[10]

 * Ornithine cyclodeaminase
[11]

 * CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase
[12]


References
Imported from IPR016040

1.Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Gibbons BJ, Hurley TD. Biochemistry 43, 12555-62, (2004). View articlePMID: 15449945

2.Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM. Biochemistry 36, 6294-304, (1997). View articlePMID: 9174344

3.Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA. J. Mol. Biol. 291, 651-60, (1999). View articlePMID: 10448043

4.High resolution structures of holo and apo formate dehydrogenase. Lamzin VS, Dauter Z, Popov VO, Harutyunyan EH, Wilson KS. J. Mol. Biol. 236, 759-85, (1994). View articlePMID: 8114093

5.CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. Stroupe ME, Leech HK, Daniels DS, Warren MJ, Getzoff ED. Nat. Struct. Biol. 10, 1064-73, (2003). View articlePMID: 14595395

6.Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL. Proteins 43, 175-85, (2001). View articlePMID: 11276087

7.Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN. FEBS J. 274, 275-86, (2007). View articlePMID: 17222187

8.The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. Yip KS, Stillman TJ, Britton KL, Artymiuk PJ, Baker PJ, Sedelnikova SE, Engel PC, Pasquo A, Chiaraluce R, Consalvi V. Structure 3, 1147-58, (1995). View articlePMID: 8591026

9.Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R. Neuron 29, 593-601, (2001). View articlePMID: 11301020

10.X-ray structure of a Rex-family repressor/NADH complex insights into the mechanism of redox sensing. Sickmier EA, Brekasis D, Paranawithana S, Bonanno JB, Paget MS, Burley SK, Kielkopf CL. Structure 13, 43-54, (2005). View articlePMID: 15642260

11.Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE. Biochemistry 43, 13883-91, (2004). View articlePMID: 15518536

12.A detailed structural description of Escherichia coli succinyl-CoA synthetase. Fraser ME, James MN, Bridger WA, Wolodko WT. J. Mol. Biol. 285, 1633-53, (1999). View articlePMID: 9917402

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