Member database | Pfam |
Pfam type | domain |
Short name | EF-hand_7 |
Clan | EF_hand |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description Imported from IPR002048
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both sides by a twelve residue α-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). Ca2 binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers
[5, 2, 1, 3, 4].
References Imported from IPR002048
1.Calcium-binding proteins 1: EF-hands. Kawasaki H, Kretsinger RH. 2, 297-490, (1995). PMID: 7553064
2.Calcium binding and conformational response in EF-hand proteins. Ikura M. Trends Biochem. Sci. 21, 14-7, (1996). View articlePMID: 8848832
3.Signal transduction versus buffering activity in Ca(2+)-binding proteins. Skelton NJ, Kordel J, Akke M, Forsen S, Chazin WJ. Nat. Struct. Biol. 1, 239-45, (1994). View articlePMID: 7656053
4.Diversity of conformational states and changes within the EF-hand protein superfamily. Yap KL, Ames JB, Swindells MB, Ikura M. Proteins 37, 499-507, (1999). View articlePMID: 10591109
5.EF-hands embrace. Kretsinger RH. Nat. Struct. Biol. 4, 514-6, (1997). View articlePMID: 9228939
Integrated to
Representative structure
4rjd: TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains