PF13854

Kelch motif

Pfam entry
Member databasePfam
Pfam typerepeat
Short nameKelch_5
ClanBeta_propeller
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0001068

Description

The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase
[1]
for which a structure has been solved
[2]
. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure
[3]
as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.

References

1.Drosophila kelch motif is derived from a common enzyme fold. Bork P, Doolittle RF. J. Mol. Biol. 236, 1277-82, (1994). View articlePMID: 8126718

2.Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase. Ito N, Phillips SE, Stevens C, Ogel ZB, McPherson MJ, Keen JN, Yadav KD, Knowles PF. Nature 350, 87-90, (1991). View articlePMID: 2002850

3.Crystal structure of the Kelch domain of human Keap1. Li X, Zhang D, Hannink M, Beamer LJ. J. Biol. Chem. 279, 54750-8, (2004). View articlePMID: 15475350

Wikipedia

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