PF13918

PLD-like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short namePLDc_3
ClanPLD
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description
Imported from IPR032803

This domain is found in a subset of the phospholipase D family members, including 5'-3' exonuclease PLD3/4 from animals
[1, 2]
and viral phospholipases such as envelope phospholipase F13 (also known as OPG057) and homologues
[4]
.

Human PLD3 is a 5'->3' DNA exonuclease which digests single-stranded DNA and may regulate inflammatory cytokine responses via the degradation of nucleic acids. PLD3 was initially thought to have phospholipase D activity due to its HKD motifs. The second HKD motif contains Glu instead of the canonical Asp and, therefore, its catalytic phospholipase D activity is still controversial
[1, 3]
. PLD4, its closest homologue, does not posses phospholipase activity.

Envelope phospholipase F13 from Vaccinia virus is the major envelope protein that plays a role in the biogenesis of the viral double membrane and in egress of virus from the host cell that produces the wrapped form of virus that is required for cell-to-cell spread
[5, 4]
. It has been shown to have broad-specificity lipase activity
[4]
.

References
Imported from IPR032803

1.PLD3 and spinocerebellar ataxia. Gonzalez AC, Stroobants S, Reisdorf P, Gavin AL, Nemazee D, Schwudke D, D'Hooge R, Saftig P, Damme M. Brain 141, e78, (2018). PMID: 30312375

2.PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Gavin AL, Huang D, Huber C, Martensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D. Nat Immunol 19, 942-953, (2018). PMID: 30111894

3.Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. Nibbeling EAR, Duarri A, Verschuuren-Bemelmans CC, Fokkens MR, Karjalainen JM, Smeets CJLM, de Boer-Bergsma JJ, van der Vries G, Dooijes D, Bampi GB, van Diemen C, Brunt E, Ippel E, Kremer B, Vlak M, Adir N, Wijmenga C, van de Warrenburg BPC, Franke L, Sinke RJ, Verbeek DS. Brain 140, 2860-2878, (2017). PMID: 29053796

4.Vaccinia Virus Phospholipase Protein F13 Promotes Rapid Entry of Extracellular Virions into Cells. Bryk P, Brewer MG, Ward BM. J Virol 92, e02154-17, (2018). PMID: 29540596

5.Retrograde Transport from Early Endosomes to the trans-Golgi Network Enables Membrane Wrapping and Egress of Vaccinia Virus Virions. Sivan G, Weisberg AS, Americo JL, Moss B. J Virol 90, 8891-905, (2016). PMID: 27466413

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