PF13922

PHD domain of transcriptional enhancer, Asx

Pfam entry
Member databasePfam
Pfam typedomain
Short namePHD_3
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description

This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.

References

1. Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. Baskind HA, Na L, Ma Q, Patel MP, Geenen DL, Wang QT. PLoS ONE 4, e4750, (2009). View articlePMID: 19270745

2. Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Fisher CL, Lee I, Bloyer S, Bozza S, Chevalier J, Dahl A, Bodner C, Helgason CD, Hess JL, Humphries RK, Brock HW. Dev. Biol. 337, 9-15, (2010). View articlePMID: 19833123

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