PF14429

C2 domain in Dock180 and Zizimin proteins

Pfam entry
Member databasePfam
Pfam typedomain
Short nameDOCK-C2
ClanC2
Author Zhang D;0000-0001-8535-7620 Aravind L;0000-0003-0771-253X
Sequence Ontology0000417

Description

The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain
[1]
[2]
.

References

1.Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. Zhang D, Aravind L. Gene 469, 18-30, (2010). View articlePMID: 20713135

2.Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Cote JF, Liddington RC. J. Biol. Chem. 285, 13211-22, (2010). View articlePMID: 20167601

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