PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

Pfam entry
Member databasePfam
Pfam typedomain
Short nameNAD_binding_11
Clan6PGD_C
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description

3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts an alpha helical structure
[1]
.

References

1.Crystal structure of novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8. Lokanath NK, Ohshima N, Takio K, Shiromizu I, Kuroishi C, Okazaki N, Kuramitsu S, Yokoyama S, Miyano M, Kunishima N. J. Mol. Biol. 352, 905-17, (2005). View articlePMID: 16126223

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