Member database | Pfam |
Pfam type | family |
Short name | NPBW |
Author | Eberhardt R;0000-0001-6152-1369 Coggill P;0000-0001-5731-1588 Hetherington K; |
Sequence Ontology | 0100021 |
Description
The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes
[1, 2].
References
1.Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. Shimomura Y, Harada M, Goto M, Sugo T, Matsumoto Y, Abe M, Watanabe T, Asami T, Kitada C, Mori M, Onda H, Fujino M. J. Biol. Chem. 277, 35826-32, (2002). View articlePMID: 12130646
2.Neuropeptide B and W regulate leptin and resistin secretion, and stimulate lipolysis in isolated rat adipocytes. Skrzypski M, Pruszynska-Oszmalek E, Rucinski M, Szczepankiewicz D, Sassek M, Wojciechowicz T, Kaczmarek P, Kolodziejski PA, Strowski MZ, Malendowicz LK, Nowak KW. Regul Pept 176, 51-6, (2012). PMID: 22484289