PF15550

Draxin

Pfam entry
Member databasePfam
Pfam typefamily
Short nameDraxin
Author Eberhardt R;0000-0001-6152-1369 Coggill P;0000-0001-5731-1588
Sequence Ontology0100021

Description

This family of proteins inhibit Wnt signaling and act as chemorepulsive axon guidance molecules [1-2].

References

1. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Islam SM, Shinmyo Y, Okafuji T, Su Y, Naser IB, Ahmed G, Zhang S, Chen S, Ohta K, Kiyonari H, Abe T, Tanaka S, Nishinakamura R, Terashima T, Kitamura T, Tanaka H. Science 323, 388-93, (2009). View articlePMID: 19150847

2. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Miyake A, Takahashi Y, Miwa H, Shimada A, Konishi M, Itoh N. Biochem. Biophys. Res. Commun. 390, 1051-5, (2009). View articlePMID: 19857465

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