Member database | Pfam |
Pfam type | family |
Short name | Draxin |
Author | Eberhardt R;0000-0001-6152-1369 Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0100021 |
Description
This family of proteins inhibit Wnt signaling and act as chemorepulsive axon guidance molecules [1-2].
References
1. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Islam SM, Shinmyo Y, Okafuji T, Su Y, Naser IB, Ahmed G, Zhang S, Chen S, Ohta K, Kiyonari H, Abe T, Tanaka S, Nishinakamura R, Terashima T, Kitamura T, Tanaka H. Science 323, 388-93, (2009). View articlePMID: 19150847
2. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Miyake A, Takahashi Y, Miwa H, Shimada A, Konishi M, Itoh N. Biochem. Biophys. Res. Commun. 390, 1051-5, (2009). View articlePMID: 19857465