PF16535

Type III cell invasion protein SipB

Pfam entry
Member databasePfam
Pfam typedomain
Short nameT3SSipB
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description

T3SSipB is a family of pathogenic Gram-negative bacterial proteins that invade human intestinal cells via the type III secretion system translocators. T3SSipB represents the coiled -coil region of the proteins and is shown to be homologous in activity to the pore-forming toxins of other Gram-negative pathogens, such as colicin Ia [1-8].

References

1. Membrane fusion activity of purified SipB, a Salmonella surface protein essential for mammalian cell invasion. Hayward RD, McGhie EJ, Koronakis V. Mol Microbiol 37, 727-39, (2000). View articlePMID: 10972796

2. A Salmonella protein causes macrophage cell death by inducing autophagy. Hernandez LD, Pypaert M, Flavell RA, Galan JE. J. Cell Biol. 163, 1123-31, (2003). View articlePMID: 14662750

3. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A. Proc. Natl. Acad. Sci. U.S.A. 96, 2396-401, (1999). View articlePMID: 10051653

4. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. Kaniga K, Tucker S, Trollinger D, Galan JE. J. Bacteriol. 177, 3965-71, (1995). View articlePMID: 7608068

5. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells. Hermant D, Menard R, Arricau N, Parsot C, Popoff MY. Mol. Microbiol. 17, 781-9, (1995). View articlePMID: 8801431

6. The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins. Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ, Picking WD, Picking WL, Geisbrecht BV. J. Mol. Biol. 417, 395-405, (2012). View articlePMID: 22321794

7. Membrane topology of Salmonella invasion protein SipB confers osmotolerance. Asakura H, Ekawa T, Sugimoto N, Momose Y, Kawamoto K, Makino S, Igimi S, Yamamoto S. Biochem Biophys Res Commun 426, 654-8, (2012). View articlePMID: 22975346

8. Multinucleated giant cell formation and apoptosis in infected host cells is mediated by Burkholderia pseudomallei type III secretion protein BipB. Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S, Lertmemongkolchai G, Bancroft GJ, Korbsrisate S. J. Bacteriol. 187, 6556-60, (2005). View articlePMID: 16159789

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