PF16607

Phosphorylation region of CYLD, unstructured

Pfam entry
Member databasePfam
Pfam typedisordered
Short nameCYLD_phos_site
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0100003

Description

CYLD_phos_site is a natively unstructured region on a subset of tumour-suppressor and de-ubiquitinating enzyme CYLD proteins in eukaryotes. It lies between the second pair of CAP_GLY domains, Pfam:PF01302, on these proteins. This region of CYLD, being unstructured, carries a number of serine residues which, in response to cellular stimuli, become phosphorylated. This transient phosphorylation-state induces ubiquitination of TRAF2, a ubiquitin ligase that catalyses both self-ubiquitination and the ubiquitination of specific target molecules involved in signal transduction
[1]
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References

1.Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Reiley W, Zhang M, Wu X, Granger E, Sun SC. Mol. Cell. Biol. 25, 3886-95, (2005). View articlePMID: 15870263

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