Member database | Pfam |
Pfam type | disordered |
Short name | CYLD_phos_site |
Author | Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0100003 |
Description
CYLD_phos_site is a natively unstructured region on a subset of tumour-suppressor and de-ubiquitinating enzyme CYLD proteins in eukaryotes. It lies between the second pair of CAP_GLY domains, Pfam:PF01302, on these proteins. This region of CYLD, being unstructured, carries a number of serine residues which, in response to cellular stimuli, become phosphorylated. This transient phosphorylation-state induces ubiquitination of TRAF2, a ubiquitin ligase that catalyses both self-ubiquitination and the ubiquitination of specific target molecules involved in signal transduction
[1].
References
1.Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Reiley W, Zhang M, Wu X, Granger E, Sun SC. Mol. Cell. Biol. 25, 3886-95, (2005). View articlePMID: 15870263