PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

Pfam entry
Member databasePfam
Pfam typedomain
Short nameNEXCaM_BD
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0000417

Description

NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD
[1]
.

References

1.Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+. Koster S, Pavkov-Keller T, Kuhlbrandt W, Yildiz O. J. Biol. Chem. 286, 40954-61, (2011). View articlePMID: 21931166

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