Member database | Pfam |
Pfam type | domain |
Short name | NEXCaM_BD |
Author | Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0000417 |
Description
NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD
[1].
References
1.Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+. Koster S, Pavkov-Keller T, Kuhlbrandt W, Yildiz O. J. Biol. Chem. 286, 40954-61, (2011). View articlePMID: 21931166