PF16689

Coiled-coil N-terminus of APC, dimerisation domain

Pfam entry
Member databasePfam
Pfam typecoiled coil
Short nameAPC_N_CC
Author Coggill P;0000-0001-5731-1588
Sequence Ontology0001080

Description

APC_N_CC is the N-terminal, coiled-coil dimerisation domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin
[1]
.

References

1.Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor. Day CL, Alber T. J. Mol. Biol. 301, 147-56, (2000). View articlePMID: 10926498

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