Member database | Pfam |
Pfam type | coiled coil |
Short name | APC_N_CC |
Author | Coggill P;0000-0001-5731-1588 |
Sequence Ontology | 0001080 |
Description
APC_N_CC is the N-terminal, coiled-coil dimerisation domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin
[1].
References
1.Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor. Day CL, Alber T. J. Mol. Biol. 301, 147-56, (2000). View articlePMID: 10926498