PF17450

Alpha galactosidase A C-terminal beta sandwich domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameMelibiase_2_C
ClanGHD
Author Coggill P;0000-0001-5731-1588 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description
Imported from IPR035373

Alpha-galactosidase (melibiase) catalyses the hydrolysis of melibiose into galactose and glucose
[3]
. Alpha-N-acetylgalactosaminidase catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides
[1]
.

This entry represents the C-terminal domain of these enzymes
[2, 4]
.

References
Imported from IPR035373

1.Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene. Wang AM, Bishop DF, Desnick RJ. J. Biol. Chem. 265, 21859-66, (1990). View articlePMID: 2174888

2.The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. Garman SC, Garboczi DN. J. Mol. Biol. 337, 319-35, (2004). View articlePMID: 15003450

3.Consideration of the evolution of the Saccharomyces cerevisiae MEL gene family on the basis of the nucleotide sequences of the genes and their flanking regions. Turakainen H, Kristo P, Korhola M. Yeast 10, 1559-68, (1994). View articlePMID: 7725791

4.The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. Clark NE, Garman SC. J. Mol. Biol. 393, 435-47, (2009). View articlePMID: 19683538

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