PF17689

Arabinosyltransferase concanavalin like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameArabino_trans_N
ClanConcanavalin
Author Waterfield DI;0000-0003-2885-5126 Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol
[1]
.

References

1.The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM. Proc. Natl. Acad. Sci. U.S.A. 93, 11919-24, (1996). View articlePMID: 8876238

Wikipedia

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