PF17856

TIP49 AAA-lid domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameTIP49_C
ClanAAA_lid
Author Moxon SJ;0000-0003-4644-1816 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway
[2]
. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases
[1]
.

References

1.Chromosome mapping and expression of human tip49 family genes. Makino Y, Kanemaki M, Koga A, Osano K, Matsu-Ura T, Kurokawa Y, Kishimoto T, Tamura T. DNA Seq. 11, 145-8, (2000). PMID: 10902922

2.Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Rottbauer W, Saurin AJ, Lickert H, Shen X, Burns CG, Wo ZG, Kemler R, Kingston R, Wu C, Fishman M. Cell 111, 661-72, (2002). View articlePMID: 12464178

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