PF17887

Jak1 pleckstrin homology-like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameJak1_Phl
ClanPH
Author El-Gebali S;0000-0003-1378-5495
Sequence Ontology0000417

Description

This entry is for the pleckstrin homology-like (PHL) subdomain found in Jak1 proteins. JAK1 is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases that are activated in response to cytokines and interferons. PHL (residues 283-419) together with the N-terminal ubiquitin-like subdomain (residues 36-111) and an acyl-coenzyme A binding protein-like subdomain (residues 148-282), associate into a canonical tri-lobed FERM domain
[1]
.

References

1.The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Ferrao R, Wallweber HJ, Ho H, Tam C, Franke Y, Quinn J, Lupardus PJ. Structure 24, 897-905, (2016). View articlePMID: 27133025

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