Member database | Pfam |
Pfam type | domain |
Short name | DTC |
Author | El-Gebali S;0000-0003-1378-5495 |
Sequence Ontology | 0000417 |
Description
This is the C-terminal domains found in members of the Deltex family of proteins which comprises five members (DTX1, 2, 3, 4, and 3L). This conserved C-terminal region of about 150 residues of the Deltex family, is preceded by a RING E3 ligase domain in four of the members. Crystal structure of the Deltex C-terminal (DTC) domain reveals a fold composed of a central beta-sheet lined with two long parallel alpha-helices
[1].
References
1.Fold of the conserved DTC domain in Deltex proteins. Obiero J, Walker JR, Dhe-Paganon S. Proteins 80, 1495-9, (2012). View articlePMID: 22411408
Integrated to
Representative structure
3pg6: The carboxyl terminal domain of human deltex 3-like