PF18196

Chromodomain helicase DNA-binding domain 1

Pfam entry
Member databasePfam
Pfam typedomain
Short nameCdh1_DBD_1
ClanHTH
Author Smart A;0000-0002-6965-5633
Sequence Ontology0000417

Description

This domain can be found in chromodomain helicase DNA-binding protein 1 (Chd1) present in Saccharomyces cerevisiae. Cdh1 proteins have been associated with the efficient assembly and spacing of nucleosomes. The domain consists of four helices, alpha helix 1-4, and can be divided into regions SANT, HL1 and the beta-linker. The HL1 region comprises of some 40 residues specific to budding yeast that are unlikely to form such a prominent feature or perform a conserved function in other species. The domain itself forms part of the DNA-binding domain. Basic residues on the alpha-1 helix are thought to be important for DNA interaction
[1]
.

References

1.The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains. Ryan DP, Sundaramoorthy R, Martin D, Singh V, Owen-Hughes T. EMBO J. 30, 2596-609, (2011). View articlePMID: 21623345

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