PF19214

Coronavirus spike glycoprotein S2, intravirion

Pfam entry
Member databasePfam
Pfam typedomain
Short nameCoV_S2_C
Author Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

This entry represents the cysteine rich intravirion region found at the C-terminus of coronavirus spike proteins (S)
[1]
. These cysteine residues are targets for palmitoylation, necessary for efficiently S incorporation into virions and S-mediated membrane fusions.

References

1.Role of spike protein endodomains in regulating coronavirus entry. Shulla A, Gallagher T. J. Biol. Chem. 284, 32725-34, (2009). PMID: 19801669

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