PF20302

HisK-N-like globin domain of the ASK signalosome

Pfam entry
Member databasePfam
Pfam typedomain
Short nameHisK-N-like
ClanGlobin
Author Aravind L;0000-0003-0771-253X Iyer LM;0000-0002-4844-2022 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

Predicted non-heme-binding version of the Globin domain identified in ASK signalosome. Displays strongest affinities to the HisK-N family of sensor domains, which inhibit histidine kinase activation required for sporulation in bacteria of the firmicutes lineage. This globin domain is predicted to represent an independent sensory element recognizing a fatty acid or a related membrane-derived molecule which regulates activity of the ASK signalosome in apoptosis
[1]
.

References

1.Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations. Burroughs AM, Aravind L. J Bacteriol 202, (2020). PMID: 32868406

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