PF20816

Picobirnavirus, Capsid protein

Pfam entry
Member databasePfam
Pfam typefamily
Short namePBV_CP
Author Lazaro Pinto Beatriz;0000-0001-6837-2941 Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

Picobirnaviruses have a unique layer with icosahedral architecture consisting of 60 quasi-symmetric dimers of a its Capsid protein (CP). This protein is organized into two domains, a shell (S) domain that contains all of the alpha-helices and two beta-sheets, and a projecting (P) domain that includes the remaining beta-sheets. The dimer is stabilised by domain swapping
[1, 2]
.

References

1.The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry. Duquerroy S, Da Costa B, Henry C, Vigouroux A, Libersou S, Lepault J, Navaza J, Delmas B, Rey FA. EMBO J. 28, 1655-65, (2009). View articlePMID: 19407816

2.Cryo-electron Microscopy Structure, Assembly, and Mechanics Show Morphogenesis and Evolution of Human Picobirnavirus. Ortega-Esteban A, Mata CP, Rodriguez-Espinosa MJ, Luque D, Irigoyen N, Rodriguez JM, de Pablo PJ, Caston JR. J Virol 94, e01542-20, (2020). PMID: 32938763

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