Member database | Pfam |
Pfam type | repeat |
Short name | CEP104-like_TOG |
Clan | TPR |
Author | Chuguransky S;0000-0002-0520-0736 |
Sequence Ontology | 0001068 |
Description
Centrosomal protein CEP104 localises to the distal end of centrioles that interacts through its N- and C-terminal region, respectively, with the distal end proteins Cep97 and CP110
[2]. It is required for ciliogenesis and for structural integrity at the ciliary tip, being involved in regulating microtubule length in cilia. This is a multidomain protein that consists of an N-terminal all-beta domain, a central all-alpha-helical TOG domain and a C-terminal array of four zinc fingers domain
[2]. This entry represents the central tubulin-binding TOG domain, consisting of HEAT repeats
[2, 3]. The sequence of TOG domains is quite divergent but the structure is conserved with some variation at the N and C-terminal
[1]. This entry also includes MEKK1 which has a TOG domain more closely related to that in CEP104, as they share a similar pair of arginine-rich C-terminal helices relative to canonical TOGs
[1]. MEKK1 TOG preferentially binds curved tubulin heterodimers
[1].
References
1.A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. Filipcik P, Latham SL, Cadell AL, Day CL, Croucher DR, Mace PD. Proc Natl Acad Sci U S A 117, 21308-21318, (2020). PMID: 32817551
Representative structure
5jo8: CEP104 TOG domain