PF21040

Centrosomal protein CEP104-like, TOG domain

Pfam entry
Member databasePfam
Pfam typerepeat
Short nameCEP104-like_TOG
ClanTPR
Author Chuguransky S;0000-0002-0520-0736
Sequence Ontology0001068

Description

Centrosomal protein CEP104 localises to the distal end of centrioles that interacts through its N- and C-terminal region, respectively, with the distal end proteins Cep97 and CP110
[2]
. It is required for ciliogenesis and for structural integrity at the ciliary tip, being involved in regulating microtubule length in cilia. This is a multidomain protein that consists of an N-terminal all-beta domain, a central all-alpha-helical TOG domain and a C-terminal array of four zinc fingers domain
[2]
. This entry represents the central tubulin-binding TOG domain, consisting of HEAT repeats
[2, 3]
. The sequence of TOG domains is quite divergent but the structure is conserved with some variation at the N and C-terminal
[1]
. This entry also includes MEKK1 which has a TOG domain more closely related to that in CEP104, as they share a similar pair of arginine-rich C-terminal helices relative to canonical TOGs
[1]
. MEKK1 TOG preferentially binds curved tubulin heterodimers
[1]
.

References

1.A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. Filipcik P, Latham SL, Cadell AL, Day CL, Croucher DR, Mace PD. Proc Natl Acad Sci U S A 117, 21308-21318, (2020). PMID: 32817551

2.The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase. Al-Jassar C, Andreeva A, Barnabas DD, McLaughlin SH, Johnson CM, Yu M, van Breugel M. Structure 25, 146-156, (2017). PMID: 28017521

3.Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network. Rezabkova L, Kraatz SH, Akhmanova A, Steinmetz MO, Kammerer RA. J Biol Chem 291, 18496-504, (2016). PMID: 27402853

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