Member database | Pfam |
Pfam type | domain |
Short name | Methyltrans_Mon_1st |
Author | Karlin D;0000-0002-3033-7013 Coggill P;0000-0001-5731-1588 Chuguransky S;0000-0002-0520-0736 |
Sequence Ontology | 0000417 |
Description
This is the connector domain (CD) from Mononegavirales single-stranded RNA viral RNA polymerase enzymes (L proteins). This domain flanks the methyltransferase domain (MT, Pfam:PF14314) and together with the C-terminal domain (CTD), in conjunction with its phosphoprotein cofactor, likely facilitates the structural rearrangements that appear to coordinate the enzymatic activities during transcription and replication
[1, 2].
References
Further reading
3. Unconventional mechanism of mRNA capping by the RNA-dependent RNA polymerase of vesicular stomatitis virus. Ogino T, Banerjee AK. Mol. Cell 25, 85-97, (2007). View articlePMID: 17218273